I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 8 studies | 40% ± 13% | |
| oligodendrocyte | 4 studies | 24% ± 8% | |
| glutamatergic neuron | 3 studies | 28% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 8 studies | 40% ± 13% | |
| oligodendrocyte | 4 studies | 24% ± 8% | |
| glutamatergic neuron | 3 studies | 28% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 91% | 759.90 | 2409 / 2642 | 44% | 1.42 | 309 / 705 |
| stomach | 69% | 228.06 | 246 / 359 | 56% | 1.67 | 161 / 286 |
| intestine | 51% | 386.20 | 492 / 966 | 66% | 1.91 | 347 / 527 |
| breast | 88% | 2347.25 | 404 / 459 | 24% | 0.67 | 263 / 1118 |
| ovary | 92% | 781.64 | 166 / 180 | 11% | 0.20 | 49 / 430 |
| adipose | 98% | 3432.94 | 1185 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 64% | 139.62 | 209 / 328 | 31% | 0.85 | 55 / 178 |
| liver | 78% | 202.56 | 176 / 226 | 10% | 0.15 | 41 / 406 |
| esophagus | 4% | 18.13 | 63 / 1445 | 79% | 3.04 | 144 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 1.72 | 31 / 45 |
| adrenal gland | 21% | 79.55 | 54 / 258 | 37% | 3.21 | 84 / 230 |
| bladder | 14% | 33.38 | 3 / 21 | 43% | 1.16 | 217 / 504 |
| skin | 21% | 63.50 | 386 / 1809 | 36% | 1.15 | 169 / 472 |
| lung | 8% | 13.32 | 45 / 578 | 46% | 1.44 | 529 / 1155 |
| muscle | 53% | 152.64 | 428 / 803 | 0% | 0 | 0 / 0 |
| uterus | 13% | 33.62 | 22 / 170 | 39% | 1.00 | 177 / 459 |
| blood vessel | 42% | 213.85 | 562 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 13% | 30.09 | 83 / 653 | 17% | 0.53 | 105 / 605 |
| kidney | 17% | 36.58 | 15 / 89 | 7% | 0.37 | 62 / 901 |
| prostate | 18% | 39.85 | 44 / 245 | 1% | 0.02 | 4 / 502 |
| eye | 0% | 0 | 0 / 0 | 16% | 0.22 | 13 / 80 |
| heart | 8% | 16.37 | 69 / 861 | 0% | 0 | 0 / 0 |
| spleen | 1% | 1.92 | 3 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 2.11 | 8 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032924 | Biological process | activin receptor signaling pathway |
| GO_0009749 | Biological process | response to glucose |
| GO_0032868 | Biological process | response to insulin |
| GO_1901164 | Biological process | negative regulation of trophoblast cell migration |
| GO_0030262 | Biological process | apoptotic nuclear changes |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0002021 | Biological process | response to dietary excess |
| GO_0046676 | Biological process | negative regulation of insulin secretion |
| GO_0043280 | Biological process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO_0019915 | Biological process | lipid storage |
| GO_0030154 | Biological process | cell differentiation |
| GO_1901383 | Biological process | negative regulation of chorionic trophoblast cell proliferation |
| GO_0038092 | Biological process | nodal signaling pathway |
| GO_0030073 | Biological process | insulin secretion |
| GO_0001834 | Biological process | trophectodermal cell proliferation |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0007399 | Biological process | nervous system development |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048179 | Cellular component | activin receptor complex |
| GO_0038100 | Molecular function | nodal binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0019838 | Molecular function | growth factor binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0016361 | Molecular function | activin receptor activity, type I |
| Gene name | ACVR1C |
| Protein name | Uncharacterized protein ACVR1C Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) |
| Synonyms | ALK7 |
| Description | FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. . |
| Accessions | ENST00000348328.9 [Q8NER5-2] Q8NER5 ENST00000243349.13 [Q8NER5-1] Q53SF5 ENST00000335450.7 [Q8NER5-3] ENST00000409680.7 [Q8NER5-4] |
