ACOX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0007283Biological processspermatogenesis
GO_0019395Biological processfatty acid oxidation
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0050665Biological processhydrogen peroxide biosynthetic process
GO_0009062Biological processfatty acid catabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0055088Biological processlipid homeostasis
GO_0006629Biological processlipid metabolic process
GO_0140493Biological processvery long-chain fatty acid beta-oxidation
GO_0033540Biological processfatty acid beta-oxidation using acyl-CoA oxidase
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0003997Molecular functionacyl-CoA oxidase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0071949Molecular functionFAD binding
GO_0016401Molecular functionpalmitoyl-CoA oxidase activity
GO_0030165Molecular functionPDZ domain binding
GO_0005504Molecular functionfatty acid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameACOX1
Protein nameAcyl-CoA oxidase 1
Peroxisomal acyl-coenzyme A oxidase 1 (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase)
Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]
SynonymsACOX
DescriptionFUNCTION: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids . Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) . .; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. .; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. .

AccessionsK7ENF1
ENST00000588968.5
I3L2U4
K7ELT1
Q15067
ENST00000301608.9 [Q15067-1]
ENST00000572047.5
I3L4S5
ENST00000576743.1
ENST00000588176.5
I3L0T4
ENST00000589301.1
ENST00000587927.5
ENST00000573078.5
ENST00000293217.10 [Q15067-2]
K7ESC7