Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 9 studies | 31% ± 7% | |
| epithelial cell | 7 studies | 30% ± 11% | |
| enterocyte | 6 studies | 26% ± 5% | |
| endothelial cell | 6 studies | 23% ± 4% | |
| macrophage | 6 studies | 17% ± 2% | |
| hepatocyte | 5 studies | 49% ± 9% | |
| squamous epithelial cell | 4 studies | 36% ± 19% | |
| basal cell | 4 studies | 17% ± 2% | |
| astrocyte | 4 studies | 26% ± 7% | |
| ionocyte | 3 studies | 24% ± 5% | |
| classical monocyte | 3 studies | 19% ± 1% | |
| retinal pigment epithelial cell | 3 studies | 20% ± 3% | |
| fibroblast | 3 studies | 19% ± 0% | |
| type I pneumocyte | 3 studies | 21% ± 3% | |
| GABAergic neuron | 3 studies | 33% ± 6% | |
| glutamatergic neuron | 3 studies | 39% ± 9% | |
| brush cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 3807.67 | 21 / 21 | 100% | 57.69 | 504 / 504 |
| esophagus | 100% | 4321.66 | 1445 / 1445 | 100% | 37.52 | 183 / 183 |
| intestine | 100% | 4679.62 | 966 / 966 | 100% | 35.78 | 527 / 527 |
| liver | 100% | 10410.19 | 226 / 226 | 100% | 69.56 | 406 / 406 |
| pancreas | 100% | 4282.90 | 328 / 328 | 100% | 41.93 | 178 / 178 |
| prostate | 100% | 3819.73 | 245 / 245 | 100% | 48.18 | 502 / 502 |
| stomach | 100% | 3812.85 | 359 / 359 | 100% | 38.08 | 286 / 286 |
| breast | 100% | 4771.46 | 459 / 459 | 100% | 34.92 | 1117 / 1118 |
| lung | 100% | 3368.63 | 576 / 578 | 100% | 33.20 | 1155 / 1155 |
| uterus | 100% | 2563.04 | 170 / 170 | 100% | 28.45 | 457 / 459 |
| thymus | 100% | 3036.96 | 652 / 653 | 100% | 33.09 | 603 / 605 |
| kidney | 100% | 3683.76 | 89 / 89 | 99% | 28.34 | 896 / 901 |
| brain | 100% | 3012.80 | 2631 / 2642 | 100% | 41.43 | 704 / 705 |
| ovary | 100% | 2400.32 | 180 / 180 | 99% | 19.58 | 424 / 430 |
| adrenal gland | 100% | 4794.29 | 258 / 258 | 97% | 20.48 | 223 / 230 |
| skin | 100% | 5090.76 | 1809 / 1809 | 96% | 21.27 | 454 / 472 |
| adipose | 100% | 5508.23 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 15.33 | 29 / 29 |
| muscle | 100% | 4515.58 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2938.66 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 23.76 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 72.47 | 1 / 1 |
| blood vessel | 100% | 2453.21 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 5209.70 | 901 / 929 | 0% | 0 | 0 / 0 |
| heart | 96% | 3051.22 | 825 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 78% | 10.97 | 62 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006091 | Biological process | generation of precursor metabolites and energy |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0019395 | Biological process | fatty acid oxidation |
| GO_0000038 | Biological process | very long-chain fatty acid metabolic process |
| GO_0050665 | Biological process | hydrogen peroxide biosynthetic process |
| GO_0009062 | Biological process | fatty acid catabolic process |
| GO_0006693 | Biological process | prostaglandin metabolic process |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0140493 | Biological process | very long-chain fatty acid beta-oxidation |
| GO_0033540 | Biological process | fatty acid beta-oxidation using acyl-CoA oxidase |
| GO_0005778 | Cellular component | peroxisomal membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005777 | Cellular component | peroxisome |
| GO_0005829 | Cellular component | cytosol |
| GO_0005782 | Cellular component | peroxisomal matrix |
| GO_0003997 | Molecular function | acyl-CoA oxidase activity |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
| GO_0071949 | Molecular function | FAD binding |
| GO_0016401 | Molecular function | palmitoyl-CoA oxidase activity |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0005504 | Molecular function | fatty acid binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ACOX1 |
| Protein name | Acyl-CoA oxidase 1 Peroxisomal acyl-coenzyme A oxidase 1 (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] |
| Synonyms | ACOX |
| Description | FUNCTION: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids . Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) . .; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. .; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. . |
| Accessions | K7ENF1 ENST00000588968.5 I3L2U4 K7ELT1 Q15067 ENST00000301608.9 [Q15067-1] ENST00000572047.5 I3L4S5 ENST00000576743.1 ENST00000588176.5 I3L0T4 ENST00000589301.1 ENST00000587927.5 ENST00000573078.5 ENST00000293217.10 [Q15067-2] K7ESC7 |