ACOT8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACOT8 at tissue level.

III. Associated gene sets

GO_0043649Biological processdicarboxylic acid catabolic process
GO_0006637Biological processacyl-CoA metabolic process
GO_0009062Biological processfatty acid catabolic process
GO_0036109Biological processalpha-linolenic acid metabolic process
GO_0016559Biological processperoxisome fission
GO_0006699Biological processbile acid biosynthetic process
GO_0045225Biological processnegative regulation of CD4 production
GO_0033540Biological processfatty acid beta-oxidation using acyl-CoA oxidase
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0052816Molecular functionlong-chain fatty acyl-CoA hydrolase activity
GO_0052689Molecular functioncarboxylic ester hydrolase activity
GO_0004778Molecular functionsuccinyl-CoA hydrolase activity
GO_0047603Molecular functionacetoacetyl-CoA hydrolase activity
GO_0047994Molecular functionhydroxymethylglutaryl-CoA hydrolase activity
GO_0052815Molecular functionmedium-chain fatty acyl-CoA hydrolase activity
GO_0016289Molecular functionacyl-CoA hydrolase activity
GO_0047617Molecular functionfatty acyl-CoA hydrolase activity
GO_0033882Molecular functioncholoyl-CoA hydrolase activity
GO_0003986Molecular functionacetyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameACOT8
Protein nameAcyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE)
palmitoyl-CoA hydrolase (EC 3.1.2.2)
Acyl-CoA thioesterase 8
SynonymsPTE1
ACTEIII
DescriptionFUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels . Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains . Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation . .; FUNCTION: (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression . .

AccessionsE9PJN0
ENST00000457981.5
O14734
ENST00000652771.1
ENST00000461272.5
E9PIS4
ENST00000487205.5
H7C5A7
ENST00000426915.1
ENST00000483141.1
E9PRD4
A0A494C0N6
F6VBM3
ENST00000488679.5
Q9BR14
H0Y698
ENST00000486165.5
ENST00000217455.9