ACOT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ACOT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACOT2 at tissue level.

III. Associated gene sets

GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0006637Biological processacyl-CoA metabolic process
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005782Cellular componentperoxisomal matrix
GO_0005739Cellular componentmitochondrion
GO_0047617Molecular functionfatty acyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0052689Molecular functioncarboxylic ester hydrolase activity

IV. Literature review

[source]
Gene nameACOT2
Protein nameAcyl-CoA thioesterase 2
Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128)
SynonymsPTE2A
PTE2
DescriptionFUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels . Displays higher activity toward long chain acyl CoAs (C14-C20) . The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). .

AccessionsA0A087WT95
P49753
F6VI00
ENST00000538782.2
ENST00000613168.1
ENST00000238651.10 [P49753-1]