ACOT13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006629Biological processlipid metabolic process
GO_0051289Biological processprotein homotetramerization
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0047617Molecular functionfatty acyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameACOT13
Protein nameAcyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]
SynonymsTHEM2
PNAS-27
HT012
DescriptionFUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels . Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) . Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) . May play a role in controlling adaptive thermogenesis (By similarity). .

AccessionsENST00000537591.5 [Q9NPJ3-2]
Q9NPJ3
ENST00000230048.5 [Q9NPJ3-1]