ACMSD report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACMSD at tissue level.

III. Associated gene sets

GO_0019748Biological processsecondary metabolic process
GO_1904985Biological processnegative regulation of quinolinate biosynthetic process
GO_0006569Biological processtryptophan catabolic process
GO_1905012Biological processregulation of 'de novo' NAD biosynthetic process from tryptophan
GO_1905004Biological processpicolinic acid biosynthetic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0001760Molecular functionaminocarboxymuconate-semialdehyde decarboxylase activity
GO_0016787Molecular functionhydrolase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameACMSD
Protein name2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase)
Synonyms
DescriptionFUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. .

FUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. .

FUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. .

AccessionsA0A0S2Z681
A0A0S2Z630
ENST00000356140.10 [Q8TDX5-1]
Q8TDX5
ENST00000392928.5 [Q8TDX5-2]