ABRAXAS1 | OmnibusX

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore
epithelial cell	3 studies	25% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABRAXAS1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	433.95	653 / 653	96%	3.46	582 / 605
breast	100%	523.58	459 / 459	94%	3.18	1049 / 1118
ovary	100%	1137.97	180 / 180	93%	2.94	399 / 430
lung	98%	313.02	568 / 578	94%	2.50	1086 / 1155
intestine	100%	438.67	966 / 966	92%	2.39	484 / 527
stomach	99%	284.24	357 / 359	92%	2.48	264 / 286
esophagus	100%	358.16	1445 / 1445	91%	1.91	166 / 183
kidney	100%	338.91	89 / 89	88%	3.42	792 / 901
brain	91%	145.42	2401 / 2642	97%	2.24	682 / 705
prostate	100%	323.89	244 / 245	87%	2.09	437 / 502
pancreas	97%	260.17	319 / 328	89%	1.94	159 / 178
skin	100%	450.88	1806 / 1809	84%	2.51	395 / 472
bladder	100%	517.76	21 / 21	73%	1.78	369 / 504
adrenal gland	100%	378.74	257 / 258	72%	1.37	166 / 230
uterus	100%	749.27	170 / 170	70%	1.51	320 / 459
adipose	100%	579.26	1204 / 1204	0%	0	0 / 0
blood vessel	100%	523.56	1335 / 1335	0%	0	0 / 0
muscle	100%	475.79	803 / 803	0%	0	0 / 0
spleen	100%	309.37	241 / 241	0%	0	0 / 0
heart	89%	170.22	769 / 861	0%	0	0 / 0
liver	47%	49.00	106 / 226	41%	0.75	168 / 406
lymph node	0%	0	0 / 0	83%	2.34	24 / 29
eye	0%	0	0 / 0	76%	2.40	61 / 80
peripheral blood	76%	226.75	703 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	67%	1.43	30 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006325	Biological process	chromatin organization
GO_0007095	Biological process	mitotic G2 DNA damage checkpoint signaling
GO_0006282	Biological process	regulation of DNA repair
GO_0090307	Biological process	mitotic spindle assembly
GO_0044818	Biological process	mitotic G2/M transition checkpoint
GO_0070536	Biological process	protein K63-linked deubiquitination
GO_0008608	Biological process	attachment of spindle microtubules to kinetochore
GO_0010212	Biological process	response to ionizing radiation
GO_0045739	Biological process	positive regulation of DNA repair
GO_0006302	Biological process	double-strand break repair
GO_0070531	Cellular component	BRCA1-A complex
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0031593	Molecular function	polyubiquitin modification-dependent protein binding
GO_0005515	Molecular function	protein binding
GO_0008017	Molecular function	microtubule binding

Gene name	ABRAXAS1
Protein name	FAM175A protein Abraxas 1, BRCA1 A complex subunit BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A)
Synonyms	FAM175A CCDC98 UNQ496/PRO1013 ABRA1
Description	FUNCTION: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. .
Accessions	ENST00000511801.1 A0A087WWJ9 D6RAN3 ENST00000506553.5 A0A087WZ78 E9PHB9 ENST00000475656.6 Q96AN9 ENST00000515303.2 Q6UWZ7 A0A087WXK1 ENST00000321945.12 [Q6UWZ7-1] ENST00000503217.2 ENST00000611288.4 D6RHI5 D6REL5 ENST00000505489.5

ABRAXAS1 report