ABCG4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCG4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	1493.36	2523 / 2642	48%	1.63	338 / 705
thymus	84%	162.91	549 / 653	53%	1.12	319 / 605
esophagus	52%	92.07	749 / 1445	10%	0.16	18 / 183
adrenal gland	11%	19.92	29 / 258	49%	2.97	113 / 230
uterus	48%	76.45	81 / 170	8%	0.20	37 / 459
heart	54%	80.66	467 / 861	0%	0	0 / 0
ovary	6%	7.86	11 / 180	41%	0.85	176 / 430
prostate	24%	30.74	58 / 245	0%	0	0 / 502
kidney	17%	27.52	15 / 89	3%	0.06	27 / 901
intestine	18%	22.78	177 / 966	1%	0.02	6 / 527
skin	12%	21.25	226 / 1809	6%	0.15	29 / 472
stomach	15%	20.23	54 / 359	1%	0.01	3 / 286
adipose	9%	10.43	104 / 1204	0%	0	0 / 0
blood vessel	7%	8.73	99 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.51	4 / 80
lung	3%	3.51	16 / 578	2%	0.03	20 / 1155
breast	3%	3.36	13 / 459	0%	0.01	4 / 1118
tonsil	0%	0	0 / 0	2%	0.04	1 / 45
bladder	0%	0	0 / 21	2%	0.04	10 / 504
liver	0%	1.14	1 / 226	1%	0.03	3 / 406
spleen	1%	1.08	2 / 241	0%	0	0 / 0
pancreas	0%	0	0 / 328	1%	0.01	1 / 178
peripheral blood	0%	1.42	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0042632	Biological process	cholesterol homeostasis
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0033344	Biological process	cholesterol efflux
GO_0071403	Biological process	cellular response to high density lipoprotein particle stimulus
GO_0045542	Biological process	positive regulation of cholesterol biosynthetic process
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0055085	Biological process	transmembrane transport
GO_0010875	Biological process	positive regulation of cholesterol efflux
GO_0010008	Cellular component	endosome membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0046982	Molecular function	protein heterodimerization activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0034041	Molecular function	ABC-type sterol transporter activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0005524	Molecular function	ATP binding

Gene name	ABCG4
Protein name	ATP binding cassette subfamily G member 4 ATP-binding cassette sub-family G member 4 (EC 7.6.2.-)
Synonyms	WHITE2
Description	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) . May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells . .
Accessions	ENST00000615496.4 [Q9H172-1] Q9H172 ENST00000524604.5 E9PJ00 ENST00000622721.1 [Q9H172-1] ENST00000619701.5 [Q9H172-1]

ABCG4 report