ABCG2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCG2 at tissue level.

III. Associated gene sets

GO_0046415Biological processurate metabolic process
GO_0030148Biological processsphingolipid biosynthetic process
GO_0032218Biological processriboflavin transport
GO_0055085Biological processtransmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0070633Biological processtransepithelial transport
GO_1990962Biological processxenobiotic transport across blood-brain barrier
GO_0015747Biological processurate transport
GO_1990748Biological processcellular detoxification
GO_0097744Biological processrenal urate salt excretion
GO_0015878Biological processbiotin transport
GO_0006869Biological processlipid transport
GO_0140115Biological processexport across plasma membrane
GO_0015711Biological processorganic anion transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0031966Cellular componentmitochondrial membrane
GO_0005654Cellular componentnucleoplasm
GO_0098591Cellular componentexternal side of apical plasma membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0046624Molecular functionsphingolipid transporter activity
GO_0015143Molecular functionurate transmembrane transporter activity
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0015225Molecular functionbiotin transmembrane transporter activity
GO_0042802Molecular functionidentical protein binding
GO_0032217Molecular functionriboflavin transmembrane transporter activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCG2
Protein nameBroad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Urate exporter)
ATP-binding cassette, sub-family G (WHITE), member 2
Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)
Breast cancer resistance protein
ATP binding cassette subfamily G member 2 (Junior blood group) (Multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2)
Multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2
SynonymsBCRP
MXR
ABCP
BCRP1
DescriptionFUNCTION: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells . Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme . Also mediates the efflux of sphingosine-1-P from cells . Acts as a urate exporter functioning in both renal and extrarenal urate excretion . In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates . Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux . In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). .

AccessionsENST00000505480.6
I7JB59
F8S0F2
F8S0F7
F8S0F6
Q8WZ76
ENST00000650821.1 [Q9UNQ0-1]
Q9UNQ0
ENST00000515655.5 [Q9UNQ0-2]
ENST00000503830.2
I4EPX2
ENST00000237612.8 [Q9UNQ0-1]