ABCD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015910Biological processlong-chain fatty acid import into peroxisome
GO_2001280Biological processpositive regulation of unsaturated fatty acid biosynthetic process
GO_0032000Biological processpositive regulation of fatty acid beta-oxidation
GO_0009617Biological processresponse to bacterium
GO_0042760Biological processvery long-chain fatty acid catabolic process
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_1990535Biological processneuron projection maintenance
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0043217Biological processmyelin maintenance
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0007031Biological processperoxisome organization
GO_0006635Biological processfatty acid beta-oxidation
GO_0005778Cellular componentperoxisomal membrane
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0005324Molecular functionlong-chain fatty acid transmembrane transporter activity
GO_0140359Molecular functionABC-type transporter activity
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0047617Molecular functionfatty acyl-CoA hydrolase activity
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCD2
Protein nameATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR)
SynonymsALDR
ALD1
ALDL1
ALDRP
DescriptionFUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen . Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) . Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) . Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation . .

AccessionsQ9UBJ2
ENST00000308666.4