ABCD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ABCD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCD1 at tissue level.

III. Associated gene sets

GO_0015910Biological processlong-chain fatty acid import into peroxisome
GO_0055092Biological processsterol homeostasis
GO_0030497Biological processfatty acid elongation
GO_0043651Biological processlinoleic acid metabolic process
GO_0055089Biological processfatty acid homeostasis
GO_2001280Biological processpositive regulation of unsaturated fatty acid biosynthetic process
GO_0032000Biological processpositive regulation of fatty acid beta-oxidation
GO_0042760Biological processvery long-chain fatty acid catabolic process
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_1990535Biological processneuron projection maintenance
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0043217Biological processmyelin maintenance
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0031998Biological processregulation of fatty acid beta-oxidation
GO_0015919Biological processperoxisomal membrane transport
GO_0007031Biological processperoxisome organization
GO_0051900Biological processregulation of mitochondrial depolarization
GO_0036109Biological processalpha-linolenic acid metabolic process
GO_0015916Biological processfatty-acyl-CoA transport
GO_0002082Biological processregulation of oxidative phosphorylation
GO_1900407Biological processregulation of cellular response to oxidative stress
GO_0006635Biological processfatty acid beta-oxidation
GO_0036113Biological processvery long-chain fatty-acyl-CoA catabolic process
GO_0042758Biological processlong-chain fatty acid catabolic process
GO_0005778Cellular componentperoxisomal membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0019899Molecular functionenzyme binding
GO_0005324Molecular functionlong-chain fatty acid transmembrane transporter activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0043531Molecular functionADP binding
GO_0015607Molecular functionABC-type fatty-acyl-CoA transporter activity
GO_0052817Molecular functionvery long-chain fatty acyl-CoA hydrolase activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0047617Molecular functionfatty acyl-CoA hydrolase activity
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCD1
Protein nameAlternative protein ABCD1
ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP)
Mutant ATP-binding cassette sub-family D member 1
ATP binding cassette subfamily D member 1
SynonymsALD
DescriptionFUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen . Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process . Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation . Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity). .

AccessionsL8E9C7
Q2PRN6
ENST00000218104.6
ENST00000370129.4
P33897
A6NEP8