ABCC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0006855Biological processxenobiotic transmembrane transport
GO_0034775Biological processglutathione transmembrane transport
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0140115Biological processexport across plasma membrane
GO_0070730Biological processcAMP transport
GO_0042908Biological processxenobiotic transport
GO_0098838Biological processfolate transmembrane transport
GO_0035351Biological processheme transmembrane transport
GO_0015865Biological processpurine nucleotide transport
GO_0030213Biological processhyaluronan biosynthetic process
GO_0070731Biological processcGMP transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005796Cellular componentGolgi lumen
GO_0010008Cellular componentendosome membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015232Molecular functionheme transmembrane transporter activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0043225Molecular functionATPase-coupled inorganic anion transmembrane transporter activity
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0015216Molecular functionpurine nucleotide transmembrane transporter activity
GO_0022884Molecular functionmacromolecule transmembrane transporter activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0034634Molecular functionglutathione transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_1901505Molecular functioncarbohydrate derivative transmembrane transporter activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCC5
Protein nameATP binding cassette subfamily C member 5
ABCC5 protein (ATP binding cassette subfamily C member 5)
ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)
SynonymsMRP5
DescriptionFUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) . Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins . Confers resistance to the antiviral agent PMEA . Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated . Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway . May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity). .

AccessionsENST00000427120.6
A5PKY6
ENST00000437205.5
ENST00000446941.2
F8WCY8
ENST00000443497.1
ENST00000438979.6
H7C271
ENST00000265586.10 [O15440-5]
O15440
ENST00000334444.11 [O15440-1]
ENST00000382494.6 [O15440-4]
ENST00000443376.5 [O15440-3]
C9JZL5
ENST00000437341.5
F8WDH3
ENST00000392579.6 [O15440-2]
E9PET4