ABCB7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070455Biological processpositive regulation of heme biosynthetic process
GO_0055085Biological processtransmembrane transport
GO_0015886Biological processheme transport
GO_1903331Biological processpositive regulation of iron-sulfur cluster assembly
GO_0034755Biological processiron ion transmembrane transport
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0016226Biological processiron-sulfur cluster assembly
GO_0006879Biological processintracellular iron ion homeostasis
GO_0140466Biological processiron-sulfur cluster export from the mitochondrion
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0015232Molecular functionheme transmembrane transporter activity
GO_0140481Molecular functionABC-type iron-sulfur cluster transporter activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCB7
Protein nameIron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial)
ATP-binding cassette sub-family B member 7 isoform 4
ATP-binding cassette sub-family B member 7 isoform 5
ATP-binding cassette sub-family B member 7 isoform 3
ATP binding cassette subfamily B member 7
Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein)
SynonymsABC7
hCG_19369
DescriptionFUNCTION: Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis . Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis . In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity). .

AccessionsENST00000643632.1
A0A0S2Z367
A0A0S2Z2W5
A0A2R8Y3N2
ENST00000534570.5
A0A087WW65
A0A2R8Y473
A0A5F9ZA98
ENST00000529949.5
E9PJR8
A0A0S2Z376
ENST00000373394.8 [O75027-1]
A0A2R8YF35
E9PNQ5
ENST00000669573.1
A0A0S2Z2Z3
O75027
ENST00000645829.3
ENST00000526404.2
A0A590UJS8
ENST00000534524.5
ENST00000620875.5
ENST00000339447.8 [O75027-3]
B4DGL8
ENST00000253577.9 [O75027-2]
ENST00000644766.1