ABCB6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ABCB6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCB6 at tissue level.

III. Associated gene sets

GO_0055085Biological processtransmembrane transport
GO_0015886Biological processheme transport
GO_0006779Biological processporphyrin-containing compound biosynthetic process
GO_0006778Biological processporphyrin-containing compound metabolic process
GO_0006785Biological processheme B biosynthetic process
GO_0035351Biological processheme transmembrane transport
GO_0042168Biological processheme metabolic process
GO_0006879Biological processintracellular iron ion homeostasis
GO_0098849Biological processcellular detoxification of cadmium ion
GO_0007420Biological processbrain development
GO_0033013Biological processtetrapyrrole metabolic process
GO_0006878Biological processintracellular copper ion homeostasis
GO_0043588Biological processskin development
GO_1903232Biological processmelanosome assembly
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0043190Cellular componentATP-binding cassette (ABC) transporter complex
GO_0005740Cellular componentmitochondrial envelope
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0033162Cellular componentmelanosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005774Cellular componentvacuolar membrane
GO_0005768Cellular componentendosome
GO_0032585Cellular componentmultivesicular body membrane
GO_0005765Cellular componentlysosomal membrane
GO_0036020Cellular componentendolysosome membrane
GO_0046906Molecular functiontetrapyrrole binding
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0140359Molecular functionABC-type transporter activity
GO_0015439Molecular functionABC-type heme transporter activity
GO_0020037Molecular functionheme binding
GO_0005524Molecular functionATP binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCB6
Protein nameATP-binding cassette sub-family B member 6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
Truncated ATP binding cassette subfamily b member 6
ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5) (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter)
ATP binding cassette subfamily B member 6 (Langereis blood group)
SynonymsMTABC3
PRP
UMAT
DescriptionFUNCTION: ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen . May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress . May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils . In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin . In addition may play a role in the transition metal homeostasis (By similarity). .

AccessionsH7C245
ENST00000448398.5
U3TD89
H7C1R6
U3TJJ6
A0A6B9LUA1
U3THP2
ENST00000443805.1
Q9NP58
ENST00000265316.9 [Q9NP58-1]
H7C049
H7C3Z0
U3THN0
A0A6B9LUM2
A0A1D9ITY9
ENST00000295750.5 [Q9NP58-4]
ENST00000417678.5
U3TGG4
U3TJK0
ENST00000452545.1