I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 72% ± 21% | |
| Mueller cell | 4 studies | 35% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 72% ± 21% | |
| Mueller cell | 4 studies | 35% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 31% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2349.53 | 226 / 226 | 82% | 25.94 | 331 / 406 |
| adipose | 82% | 264.42 | 984 / 1204 | 0% | 0 | 0 / 0 |
| breast | 68% | 160.86 | 310 / 459 | 2% | 0.06 | 20 / 1118 |
| skin | 58% | 47.60 | 1054 / 1809 | 0% | 0 | 0 / 472 |
| intestine | 30% | 103.20 | 294 / 966 | 2% | 0.10 | 12 / 527 |
| bladder | 10% | 2.62 | 2 / 21 | 5% | 0.08 | 23 / 504 |
| heart | 14% | 6.14 | 119 / 861 | 0% | 0 | 0 / 0 |
| stomach | 4% | 3.00 | 16 / 359 | 3% | 0.09 | 10 / 286 |
| esophagus | 3% | 1.39 | 48 / 1445 | 4% | 0.07 | 7 / 183 |
| blood vessel | 7% | 6.47 | 93 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 6% | 3.26 | 38 / 653 | 0% | 0.03 | 3 / 605 |
| muscle | 6% | 3.45 | 50 / 803 | 0% | 0 | 0 / 0 |
| prostate | 5% | 2.75 | 12 / 245 | 1% | 0.02 | 5 / 502 |
| brain | 3% | 1.54 | 81 / 2642 | 2% | 0.04 | 13 / 705 |
| lung | 2% | 0.53 | 11 / 578 | 2% | 0.07 | 24 / 1155 |
| adrenal gland | 3% | 1.22 | 8 / 258 | 0% | 0.01 | 1 / 230 |
| pancreas | 0% | 0 | 0 / 328 | 3% | 0.06 | 6 / 178 |
| uterus | 0% | 0 | 0 / 170 | 3% | 0.07 | 15 / 459 |
| spleen | 2% | 5.62 | 6 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 2% | 0.56 | 17 / 929 | 0% | 0 | 0 / 0 |
| ovary | 1% | 0.32 | 2 / 180 | 1% | 0.02 | 3 / 430 |
| kidney | 1% | 0.71 | 1 / 89 | 1% | 0.04 | 5 / 901 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0055091 | Biological process | phospholipid homeostasis |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0034219 | Biological process | carbohydrate transmembrane transport |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0006855 | Biological process | xenobiotic transmembrane transport |
| GO_1904251 | Biological process | regulation of bile acid metabolic process |
| GO_0008206 | Biological process | bile acid metabolic process |
| GO_0043627 | Biological process | response to estrogen |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0120189 | Biological process | positive regulation of bile acid secretion |
| GO_0014070 | Biological process | response to organic cyclic compound |
| GO_0045471 | Biological process | response to ethanol |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0015721 | Biological process | bile acid and bile salt transport |
| GO_0038183 | Biological process | bile acid signaling pathway |
| GO_0031998 | Biological process | regulation of fatty acid beta-oxidation |
| GO_0015722 | Biological process | canalicular bile acid transport |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0006699 | Biological process | bile acid biosynthetic process |
| GO_0046618 | Biological process | xenobiotic export from cell |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0046581 | Cellular component | intercellular canaliculus |
| GO_0005768 | Cellular component | endosome |
| GO_0046691 | Cellular component | intracellular canaliculus |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0015125 | Molecular function | bile acid transmembrane transporter activity |
| GO_0015432 | Molecular function | ABC-type bile acid transporter activity |
| GO_0008559 | Molecular function | ABC-type xenobiotic transporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0015144 | Molecular function | carbohydrate transmembrane transporter activity |
| GO_0015126 | Molecular function | canalicular bile acid transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | ABCB11 |
| Protein name | Bile salt export pump Bile salt export pump (EC 7.6.2.-) (ATP-binding cassette sub-family B member 11) ATP binding cassette subfamily B member 11 |
| Synonyms | BSEP |
| Description | FUNCTION: Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner . Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts . Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion . . |
| Accessions | Q53S60 O95342 ENST00000649448.1 ENST00000618180.1 ENST00000439188.1 ENST00000648875.1 ENST00000647920.1 A0A3B3ISD4 H7C486 A0A3B3ITV9 ENST00000650372.1 A0A2U9Q1W5 A0A3B3IS78 |
