ABCB10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048821Biological processerythrocyte development
GO_0006839Biological processmitochondrial transport
GO_0070455Biological processpositive regulation of heme biosynthetic process
GO_0046985Biological processpositive regulation of hemoglobin biosynthetic process
GO_0006783Biological processheme biosynthetic process
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_0034514Biological processmitochondrial unfolded protein response
GO_0055085Biological processtransmembrane transport
GO_0031966Cellular componentmitochondrial membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0042803Molecular functionprotein homodimerization activity
GO_0140359Molecular functionABC-type transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameABCB10
Protein nameATP-binding cassette sub-family B member 10, mitochondrial (ABC-mitochondrial erythroid protein) (ABC-me protein) (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2)
Synonyms
DescriptionFUNCTION: Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner . May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria . Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress . In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria . .

AccessionsENST00000344517.5
Q9NRK6