ABCA8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006686Biological processsphingomyelin biosynthetic process
GO_0006855Biological processxenobiotic transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0006869Biological processlipid transport
GO_0042908Biological processxenobiotic transport
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0010874Biological processregulation of cholesterol efflux
GO_0033344Biological processcholesterol efflux
GO_0030301Biological processcholesterol transport
GO_0005886Cellular componentplasma membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016323Cellular componentbasolateral plasma membrane
GO_0140359Molecular functionABC-type transporter activity
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0005524Molecular functionATP binding
GO_0005319Molecular functionlipid transporter activity
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCA8
Protein nameATP binding cassette subfamily A member 8
ABCA8 protein
ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8)
SynonymsKIAA0822
DescriptionFUNCTION: [Isoform 1]: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate . In vitro, also imports ochratoxin A . Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes . .; FUNCTION: [Isoform 3]: Catalyzes ATP-dependent efflux of cholesterol and taurocholate . Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels . .

AccessionsO94911
ENST00000585531.1
K7ELK9
ENST00000586539.6 [O94911-3]
A0A075B774
ENST00000269080.6 [O94911-1]
Q49AI9
ENST00000589533.5
ENST00000430352.6
A0A0A0MSU4