Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 34 studies | 42% ± 19% | |
| oligodendrocyte | 16 studies | 54% ± 19% | |
| adipocyte | 8 studies | 36% ± 8% | |
| connective tissue cell | 7 studies | 33% ± 10% | |
| glial cell | 7 studies | 37% ± 16% | |
| type I pneumocyte | 7 studies | 27% ± 7% | |
| endothelial cell | 6 studies | 25% ± 9% | |
| adventitial cell | 5 studies | 46% ± 4% | |
| Mueller cell | 5 studies | 31% ± 9% | |
| mesothelial cell | 4 studies | 27% ± 12% | |
| pericyte | 4 studies | 22% ± 8% | |
| hepatocyte | 3 studies | 45% ± 9% | |
| astrocyte | 3 studies | 22% ± 7% | |
| smooth muscle cell | 3 studies | 41% ± 16% | |
| myofibroblast cell | 3 studies | 21% ± 4% | |
| Schwann cell | 3 studies | 66% ± 16% | |
| cardiac muscle cell | 3 studies | 20% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 88% | 2990.92 | 216 / 245 | 89% | 4.14 | 448 / 502 |
| thymus | 98% | 5733.67 | 639 / 653 | 73% | 3.94 | 444 / 605 |
| liver | 94% | 3014.53 | 213 / 226 | 69% | 5.55 | 280 / 406 |
| adrenal gland | 99% | 9255.75 | 255 / 258 | 60% | 6.60 | 137 / 230 |
| breast | 99% | 6926.74 | 453 / 459 | 52% | 2.51 | 583 / 1118 |
| lung | 96% | 4777.43 | 555 / 578 | 50% | 2.10 | 572 / 1155 |
| brain | 45% | 1473.46 | 1176 / 2642 | 98% | 10.06 | 689 / 705 |
| ovary | 100% | 12382.92 | 180 / 180 | 20% | 0.52 | 86 / 430 |
| bladder | 95% | 5138.95 | 20 / 21 | 23% | 0.79 | 118 / 504 |
| skin | 71% | 2877.27 | 1287 / 1809 | 47% | 10.30 | 222 / 472 |
| esophagus | 81% | 4881.34 | 1176 / 1445 | 36% | 1.45 | 66 / 183 |
| intestine | 92% | 4266.48 | 887 / 966 | 23% | 0.96 | 120 / 527 |
| stomach | 79% | 3289.65 | 284 / 359 | 32% | 1.81 | 91 / 286 |
| uterus | 88% | 3452.52 | 150 / 170 | 17% | 0.50 | 80 / 459 |
| kidney | 45% | 1347.18 | 40 / 89 | 59% | 2.86 | 536 / 901 |
| adipose | 100% | 9292.91 | 1198 / 1204 | 0% | 0 | 0 / 0 |
| heart | 99% | 7600.57 | 849 / 861 | 0% | 0 | 0 / 0 |
| spleen | 93% | 3300.54 | 225 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 86% | 3762.12 | 1142 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 7% | 147.76 | 24 / 328 | 76% | 4.33 | 136 / 178 |
| eye | 0% | 0 | 0 / 0 | 78% | 14.31 | 62 / 80 |
| muscle | 62% | 1459.91 | 499 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 0.32 | 8 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.05 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006686 | Biological process | sphingomyelin biosynthetic process |
| GO_0006855 | Biological process | xenobiotic transmembrane transport |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0006869 | Biological process | lipid transport |
| GO_0042908 | Biological process | xenobiotic transport |
| GO_0010875 | Biological process | positive regulation of cholesterol efflux |
| GO_0010874 | Biological process | regulation of cholesterol efflux |
| GO_0033344 | Biological process | cholesterol efflux |
| GO_0030301 | Biological process | cholesterol transport |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0140359 | Molecular function | ABC-type transporter activity |
| GO_0008559 | Molecular function | ABC-type xenobiotic transporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005319 | Molecular function | lipid transporter activity |
| GO_0042626 | Molecular function | ATPase-coupled transmembrane transporter activity |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | ABCA8 |
| Protein name | ATP binding cassette subfamily A member 8 ABCA8 protein ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8) |
| Synonyms | KIAA0822 |
| Description | FUNCTION: [Isoform 1]: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate . In vitro, also imports ochratoxin A . Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes . .; FUNCTION: [Isoform 3]: Catalyzes ATP-dependent efflux of cholesterol and taurocholate . Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels . . |
| Accessions | O94911 ENST00000585531.1 K7ELK9 ENST00000586539.6 [O94911-3] A0A075B774 ENST00000269080.6 [O94911-1] Q49AI9 ENST00000589533.5 ENST00000430352.6 A0A0A0MSU4 |