AARS2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AARS2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AARS2 at tissue level.

III. Associated gene sets

GO_0106074Biological processaminoacyl-tRNA metabolism involved in translational fidelity
GO_0006419Biological processalanyl-tRNA aminoacylation
GO_0070143Biological processmitochondrial alanyl-tRNA aminoacylation
GO_0005739Cellular componentmitochondrion
GO_0000049Molecular functiontRNA binding
GO_0002161Molecular functionaminoacyl-tRNA editing activity
GO_0005515Molecular functionprotein binding
GO_0004813Molecular functionalanine-tRNA ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameAARS2
Protein nameAlanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)
AARS2 protein
SynonymsKIAA1270
AARSL
DescriptionFUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. .

AccessionsA2VCL8
ENST00000244571.5
Q5JTZ9