AARS1 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	5 studies	41% ± 23%	Explore
astrocyte	5 studies	22% ± 6%	Explore
plasma cell	4 studies	26% ± 10%	Explore
neuron	4 studies	25% ± 7%	Explore
endothelial cell	4 studies	21% ± 3%	Explore
retinal ganglion cell	4 studies	43% ± 25%	Explore
GABAergic neuron	4 studies	41% ± 17%	Explore
oligodendrocyte	4 studies	21% ± 5%	Explore
epithelial cell	3 studies	24% ± 1%	Explore
abnormal cell	3 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 4%	Explore
interneuron	3 studies	36% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	32% ± 14%	Explore
eye	3 studies	18% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	11614.08	2640 / 2642	100%	104.72	705 / 705
esophagus	100%	6830.13	1443 / 1445	100%	49.78	183 / 183
uterus	100%	8516.45	170 / 170	100%	60.45	458 / 459
skin	100%	8056.40	1806 / 1809	100%	81.59	471 / 472
prostate	100%	7514.31	244 / 245	100%	60.72	502 / 502
lung	100%	8381.31	577 / 578	100%	59.85	1152 / 1155
breast	100%	7572.43	459 / 459	100%	59.36	1113 / 1118
intestine	100%	7196.94	965 / 966	100%	54.02	525 / 527
thymus	100%	11748.79	653 / 653	100%	61.88	602 / 605
pancreas	100%	6594.08	328 / 328	99%	47.83	177 / 178
stomach	100%	6925.67	359 / 359	99%	48.58	284 / 286
kidney	100%	6191.27	89 / 89	99%	47.26	894 / 901
liver	100%	6705.36	225 / 226	99%	48.21	403 / 406
adrenal gland	100%	9196.07	258 / 258	99%	55.33	227 / 230
bladder	100%	8082.67	21 / 21	99%	51.16	497 / 504
ovary	100%	6333.03	180 / 180	97%	37.45	419 / 430
adipose	100%	7532.99	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7379.63	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	61.67	80 / 80
lymph node	0%	0	0 / 0	100%	52.49	29 / 29
muscle	100%	6231.46	803 / 803	0%	0	0 / 0
spleen	100%	6628.03	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	53.50	45 / 45
ureter	0%	0	0 / 0	100%	28.74	1 / 1
heart	95%	5322.39	817 / 861	0%	0	0 / 0
peripheral blood	46%	4692.98	428 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006419	Biological process	alanyl-tRNA aminoacylation
GO_0140018	Biological process	regulation of cytoplasmic translational fidelity
GO_0050885	Biological process	neuromuscular process controlling balance
GO_0051402	Biological process	neuron apoptotic process
GO_0006400	Biological process	tRNA modification
GO_0006418	Biological process	tRNA aminoacylation for protein translation
GO_0008033	Biological process	tRNA processing
GO_0106074	Biological process	aminoacyl-tRNA metabolism involved in translational fidelity
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0021680	Biological process	cerebellar Purkinje cell layer development
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004813	Molecular function	alanine-tRNA ligase activity
GO_0016597	Molecular function	amino acid binding
GO_0008270	Molecular function	zinc ion binding
GO_0005524	Molecular function	ATP binding
GO_0002196	Molecular function	Ser-tRNA(Ala) hydrolase activity
GO_0000049	Molecular function	tRNA binding
GO_0002161	Molecular function	aminoacyl-tRNA editing activity

IV. Literature review

[source]

Gene name	AARS1
Protein name	alanine--tRNA ligase (EC 6.1.1.7) Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42) Alanine--tRNA ligase (EC 6.1.1.7) Alanyl-tRNA synthetase 1
Synonyms	AARS
Description	FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) . Also edits incorrectly charged tRNA(Ala) via its editing domain . . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. . FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. .
Accessions	A0A6Q8PGE8 ENST00000676247.1 ENST00000674691.1 [P49588-1] ENST00000676209.1 A0A6Q8PGR9 H3BPK7 ENST00000675569.1 ENST00000675035.1 A0A6Q8PF33 ENST00000676212.1 ENST00000675853.1 ENST00000675371.1 A0A6Q8PHP3 ENST00000674512.1 A0A6Q8PFK3 ENST00000675133.1 A0A6Q8PHP7 ENST00000675120.1 A0A6Q8PG28 A0A6Q8PGN5 ENST00000676004.1 ENST00000676040.1 A0A6Q8PFY2 ENST00000674963.1 [P49588-1] A0A6Q8PG62 ENST00000676211.1 ENST00000676168.1 ENST00000674811.1 ENST00000675691.1 ENST00000674768.1 A0A6Q8PF77 A0A6Q8PH44 ENST00000675297.1 ENST00000674652.1 ENST00000675643.1 [P49588-1] ENST00000565361.3 ENST00000675953.1 ENST00000261772.13 [P49588-1] P49588 A0A6Q8PGI8 A0A6Q8PGB5 ENST00000675045.1 ENST00000675751.1 A0A6Q8PHJ2 A0A6Q8PHN5

AARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review