Name | STING complex |
ID | GO_1990231 |
collection_id | Cellular component |
Exact synonym | stimulator of interferon genes complex |
Description | A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. |
External URL | |
Genes |