STING complex

I. Literature review

[source]
NameSTING complex
IDGO_1990231
collection_id

Cellular component

Exact synonym

stimulator of interferon genes complex

Description

A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response.

External URL
Genes