Biological process

down regulation of MHC class I biosynthetic process, down-regulation of MHC class I biosynthetic process, downregulation of MHC class I biosynthetic process, negative regulation of MHC class I anabolism, negative regulation of MHC class I biosynthesis, negative regulation of MHC class I formation, negative regulation of MHC class I synthesis, negative regulation of major histocompatibility complex class I biosynthesis, negative regulation of major histocompatibility complex class I biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.