Insulin is expressed by enteroendocrine cells during human fetal development
Adi Egozi, Dhana Llivichuzhca-Loja, Blake T. McCourt, Keren Bahar Halpern, Lydia Farack, Xiaojing An, Fujing Wang, Kong Chen, Liza Konnikova, Shalev Itzkovitz
Abstract
Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.
Datasets
1. fetal and neonatal human small intestine cells
Metadata
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19 weeks (post-conception)18151 cells 21 weeks (post-conception)12224 cells NCBITaxon:960636359 cells bec32274-7c75-43b7-80d3-33246f9db8b510456 cells 3c16641d-8788-4fcf-8dda-780e9de59ccc7695 cells b0f559e8-b261-4f19-be4b-4509686ae4e16294 cells cf1a3e0d-56b6-4647-9bea-99986dc2a30e5930 cells 8876c3cb-113a-4cb3-b102-dbd6e3bc6f275402 cells 4f41ab8b-6dd8-4a13-a501-8e669fec205a582 cells cryopreservation36359 cells UBERON:000210836359 cells HsapDv:000005718151 cells HsapDv:000005912224 cells b805a8c8-7821-457a-9a32-3c0508b6d05b9085 cells ddd6e390-125e-49a7-97ba-361265bf669a6970 cells a7c4f71b-097f-4675-86b4-704e9b1d4f355696 cells 3c0d4351-baf3-4088-8735-96b9382be7184818 cells 2032ec98-1b57-4580-86fb-43f866b6605e4787 cells 7b498596-6ade-411a-90a2-496132afb64a1371 cells 6107bb63-b1af-48d6-8c74-57a158806dbc1143 cells 53041dc4-94d0-4641-872b-1d215fcc9332725 cells c8326897-6b05-4285-beb7-adc1b898e9f2598 cells ebf99eae-37c3-436d-93e5-8df392d30310584 cells ee2b2b99-14ee-43d1-9406-b530872e3cfb380 cells d734b886-ce27-473d-af94-f5fcdcb0e8ab202 cells 29b0830a-6fbc-4c45-9c6a-dff3b9ac157d9085 cells ed53b6eb-bb89-4f0c-8cfb-8a80542bba186970 cells 4608c76c-17d2-43b8-9fd8-d7dc4984f6045696 cells 6fa50b98-5d26-4f60-8b99-832889e4d9294818 cells 4e19963d-80e0-4cc3-8250-fff3dfa23f504787 cells cc4ff9dc-b76e-4e50-a2df-198946c334041371 cells 55cda4b5-beac-4654-86c3-d677b627a6661143 cells 72836128-036b-4f69-812b-e28ffa0355f2725 cells 0b968752-0ca6-420d-897f-e931cf0479db598 cells d4b4b8f5-f511-43f1-a846-ac12da49b64a584 cells e8e51f44-880a-477e-8218-f65577fb5130380 cells 540d9092-b3ab-4f84-b746-a1433b845803202 cells Lymphatic Endothelial cells1339 cells Endothelial cells1308 cells Dividing T/NK cells880 cells endothelial cell of lymphatic vessel1339 cells blood vessel endothelial cell1308 cells enteroendocrine cell781 cells small intestine36359 cells 20th week post-fertilization human stage18151 cells 22nd week post-fertilization human stage12224 cells newborn human stage5984 cells Analyze this study
Source data
https://cellxgene.cziscience.com/collections/7651ac1a-f947-463a-9223-a9e408a41989
Alias names
PMID34887578
Cite this study
Egozi, A., Llivichuzhca-Loja, D., McCourt, B.T., Bahar Halpern, K., Farack, L., An, X., Wang, F., Chen, K., Konnikova, L. and Itzkovitz, S., 2021. Insulin is expressed by enteroendocrine cells during human fetal development. Nature medicine, 27(12), pp.2104-2107. https://doi.org/10.1038/s41591-021-01586-1
