ZNRF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070936Biological processprotein K48-linked ubiquitination
GO_0061909Biological processautophagosome-lysosome fusion
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0042995Cellular componentcell projection
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0042734Cellular componentpresynaptic membrane
GO_0005886Cellular componentplasma membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0001650Cellular componentfibrillar center
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNRF2
Protein nameE3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
SynonymshCG_1801423
tcag7.1251
RNF202
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation . Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases . In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism . .

AccessionsQ8NHG8
A0A090N8Y8
ENST00000323037.5