Name | Number of supported studies | Average coverage | |
---|---|---|---|
microglial cell | 10 studies | 49% ± 16% | |
macrophage | 8 studies | 36% ± 16% | |
endothelial cell | 7 studies | 26% ± 10% | |
myeloid cell | 7 studies | 21% ± 4% | |
retinal cone cell | 7 studies | 31% ± 12% | |
epithelial cell | 5 studies | 39% ± 16% | |
dendritic cell | 5 studies | 22% ± 8% | |
plasmacytoid dendritic cell | 5 studies | 21% ± 2% | |
interneuron | 4 studies | 35% ± 19% | |
astrocyte | 4 studies | 37% ± 10% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 11% | |
oligodendrocyte | 4 studies | 28% ± 8% | |
CD4-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
lymphocyte | 3 studies | 25% ± 10% | |
GABAergic neuron | 3 studies | 46% ± 11% | |
glutamatergic neuron | 3 studies | 63% ± 7% | |
CD8-positive, alpha-beta T cell | 3 studies | 16% ± 0% | |
natural killer cell | 3 studies | 17% ± 2% | |
monocyte | 3 studies | 25% ± 3% | |
type I pneumocyte | 3 studies | 22% ± 5% | |
transit amplifying cell | 3 studies | 34% ± 20% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 6 studies | 38% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 849.64 | 359 / 359 | 100% | 24.57 | 286 / 286 |
esophagus | 100% | 839.46 | 1444 / 1445 | 100% | 29.43 | 183 / 183 |
ovary | 100% | 473.50 | 180 / 180 | 100% | 17.96 | 429 / 430 |
intestine | 100% | 1021.63 | 966 / 966 | 100% | 21.31 | 525 / 527 |
lung | 100% | 798.45 | 576 / 578 | 100% | 18.60 | 1153 / 1155 |
breast | 100% | 888.07 | 459 / 459 | 99% | 25.32 | 1112 / 1118 |
liver | 100% | 1342.54 | 226 / 226 | 99% | 15.51 | 402 / 406 |
bladder | 100% | 783.62 | 21 / 21 | 99% | 17.82 | 499 / 504 |
kidney | 100% | 1552.65 | 89 / 89 | 99% | 17.67 | 892 / 901 |
thymus | 100% | 1107.06 | 653 / 653 | 99% | 25.45 | 598 / 605 |
pancreas | 100% | 754.85 | 327 / 328 | 99% | 14.19 | 176 / 178 |
prostate | 100% | 628.52 | 245 / 245 | 98% | 13.56 | 492 / 502 |
uterus | 100% | 695.06 | 170 / 170 | 98% | 15.34 | 449 / 459 |
adrenal gland | 100% | 679.49 | 258 / 258 | 91% | 9.50 | 210 / 230 |
brain | 97% | 378.15 | 2560 / 2642 | 84% | 6.80 | 589 / 705 |
skin | 100% | 931.83 | 1807 / 1809 | 80% | 6.96 | 378 / 472 |
adipose | 100% | 798.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 15.70 | 29 / 29 |
spleen | 100% | 832.98 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 13.90 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.82 | 1 / 1 |
muscle | 100% | 603.58 | 801 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 617.82 | 1328 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 91% | 617.56 | 848 / 929 | 0% | 0 | 0 / 0 |
heart | 91% | 342.55 | 785 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 10% | 0.46 | 8 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0061909 | Biological process | autophagosome-lysosome fusion |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0042995 | Cellular component | cell projection |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0010008 | Cellular component | endosome membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0042734 | Cellular component | presynaptic membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0001650 | Cellular component | fibrillar center |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0046872 | Molecular function | metal ion binding |
Gene name | ZNRF2 |
Protein name | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) RING-type E3 ubiquitin transferase (EC 2.3.2.27) |
Synonyms | hCG_1801423 tcag7.1251 RNF202 |
Description | FUNCTION: E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation . Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases . In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism . . |
Accessions | Q8NHG8 A0A090N8Y8 ENST00000323037.5 |