ZNG1F report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNG1F at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNG1F at tissue level.

III. Associated gene sets

GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0016787Molecular functionhydrolase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNG1F
Protein nameZinc-regulated GTPase metalloprotein activator 1F (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 6) (COBW domain-containing protein 6)
Zn regulated GTPase metalloprotein activator 1C (Zn regulated GTPase metalloprotein activator 1F)
Zn regulated GTPase metalloprotein activator 1F
SynonymsCBWD6
CBWD7
ZNG1C
DescriptionFUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (By similarity). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation . Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (By similarity). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1F to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (By similarity). GTP/GDP exchange is required for release of active METAP1 (By similarity). .

AccessionsENST00000621474.4
ENST00000377391.8
ENST00000616550.4
A0A087WU66
ENST00000486387.6
ENST00000620776.4
ENST00000382436.7
A0A0B4J2E3
Q4V339
ENST00000467791.5
H0Y5V3
A0A087WX94
A0A087X1C0
ENST00000456520.5
ENST00000621396.4