ZER1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex

IV. Literature review

[source]
Gene nameZER1
Protein nameZER1 protein
Zyg-11 related cell cycle regulator
Protein zer-1 homolog (Hzyg) (Zyg-11 homolog B-like protein) (Zyg11b-like protein)
SynonymsC9orf60
ZYG
ZYG11BL
DescriptionFUNCTION: Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC . Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements . Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation . .

AccessionsENST00000427848.1
ENST00000291900.7
ENST00000414921.5
X6RC68
Q05BR7
X6RD87
Q7Z7L7