ZDHHC8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZDHHC8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZDHHC8 at tissue level.

III. Associated gene sets

GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0018345Biological processprotein palmitoylation
GO_0034380Biological processhigh-density lipoprotein particle assembly
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0044794Biological processpositive regulation by host of viral process
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0007626Biological processlocomotory behavior
GO_0031966Cellular componentmitochondrial membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity

IV. Literature review

[source]
Gene nameZDHHC8
Protein nameZDHHC8 protein
Palmitoyltransferase (EC 2.3.1.225)
Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)
SynonymsZDHHCL1
ZNF378
KIAA1292
DescriptionFUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). .; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. .

AccessionsQ9ULC8
Q96GI9
C9JVM2
ENST00000320602.11 [Q9ULC8-2]
ENST00000436518.5
ENST00000334554.12 [Q9ULC8-1]
ENST00000405930.3 [Q9ULC8-3]