XKR8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of XKR8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of XKR8 at tissue level.

III. Associated gene sets

GO_1902742Biological processapoptotic process involved in development
GO_0002513Biological processtolerance induction to self antigen
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0070782Biological processphosphatidylserine exposure on apoptotic cell surface
GO_0043652Biological processengulfment of apoptotic cell
GO_0051649Biological processestablishment of localization in cell
GO_0097350Biological processneutrophil clearance
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0017128Molecular functionphospholipid scramblase activity

IV. Literature review

[source]
Gene nameXKR8
Protein nameXK-related protein
XK-related protein 8 (hXkr8) [Cleaved into: XK-related protein 8, processed form]
SynonymshCG_1818011
XRG8
DescriptionFUNCTION: [XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface . Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment . Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity). Has no effect on calcium-induced exposure of phosphatidylserine . Promotes myoblast differentiation and survival . .; FUNCTION: (Microbial infection) Incorporated into Ebola virus-like particles, where its phospholipid scramblase activity is required to promote phosphatidylserine exposure on the surface of viral particles . Externalization of phosphatidylserine on the surface of viral particles is required for uptake by host cells . .

AccessionsENST00000676017.1
A0A6Q8PGH8
A0A6Q8PHM3
A0A6Q8PFG6
ENST00000373884.6
ENST00000675282.1
ENST00000676058.1
ENST00000675359.1
ENST00000675759.1
ENST00000675575.1
A0A6Q8PH47
A0A6Q8PGR5
Q9H6D3
Q9NW55