VCPIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006974Biological processDNA damage response
GO_0016579Biological processprotein deubiquitination
GO_0071108Biological processprotein K48-linked deubiquitination
GO_0035871Biological processprotein K11-linked deubiquitination
GO_1905634Biological processregulation of protein localization to chromatin
GO_0090168Biological processGolgi reassembly
GO_0016320Biological processendoplasmic reticulum membrane fusion
GO_0006508Biological processproteolysis
GO_0106300Biological processprotein-DNA covalent cross-linking repair
GO_0005795Cellular componentGolgi stack
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameVCPIP1
Protein nameDeubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein)
SynonymsVCIP135
KIAA1850
DescriptionFUNCTION: Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis . Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) . Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains . .; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. .

AccessionsENST00000310421.5
Q96JH7