USP51 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of USP51 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP51 at tissue level.

III. Associated gene sets

GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_0006974Biological processDNA damage response
GO_2001032Biological processregulation of double-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_0010564Biological processregulation of cell cycle process
GO_0006508Biological processproteolysis
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0140950Molecular functionhistone H2A deubiquitinase activity
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0008270Molecular functionzinc ion binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameUSP51
Protein nameUbiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51)
Synonyms
DescriptionFUNCTION: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) . USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin . .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsQ70EK9
ENST00000500968.4
ENST00000586165.1
A0A1B0GVA6