USP35 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of USP35 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP35 at tissue level.

III. Associated gene sets

GO_0006508Biological processproteolysis
GO_0016579Biological processprotein deubiquitination
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP35
Protein nameUbiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35)
USP35 protein
Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin specific peptidase 35
SynonymsUSP34
KIAA1372
DescriptionFUNCTION: Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress . Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination . Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein . In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability . Regulates the degradation of mitochondria through the process of autophagy termed mitophagy . .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsE9PRM2
ENST00000529308.6 [Q9P2H5-1]
A2RRA6
ENST00000528910.5
Q9P2H5
H0YEP1
E9PK78
ENST00000530267.5
ENST00000526425.1 [Q9P2H5-2]
ENST00000530546.5