UPB1 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	4 studies	56% ± 23%	Explore
epithelial cell of proximal tubule	3 studies	23% ± 8%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of UPB1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	12493.56	226 / 226	90%	66.24	364 / 406
kidney	100%	2377.24	89 / 89	60%	9.64	541 / 901
lung	99%	164.92	573 / 578	4%	0.15	51 / 1155
uterus	87%	63.29	148 / 170	15%	0.46	68 / 459
spleen	100%	150.57	240 / 241	0%	0	0 / 0
peripheral blood	99%	362.10	921 / 929	0%	0	0 / 0
heart	99%	206.22	849 / 861	0%	0	0 / 0
muscle	91%	57.67	731 / 803	0%	0	0 / 0
prostate	89%	63.34	219 / 245	0%	0	0 / 502
stomach	79%	38.42	282 / 359	5%	0.17	14 / 286
brain	82%	57.92	2163 / 2642	1%	0.01	6 / 705
thymus	69%	35.62	450 / 653	9%	0.26	55 / 605
ovary	77%	47.68	139 / 180	0%	0	0 / 430
blood vessel	76%	44.02	1013 / 1335	0%	0	0 / 0
intestine	71%	39.66	687 / 966	3%	0.13	14 / 527
adipose	73%	42.27	880 / 1204	0%	0	0 / 0
breast	67%	33.43	307 / 459	1%	0.03	13 / 1118
esophagus	61%	37.02	888 / 1445	3%	0.08	5 / 183
tonsil	0%	0	0 / 0	58%	2.75	26 / 45
adrenal gland	51%	28.60	131 / 258	6%	0.21	14 / 230
bladder	52%	24.67	11 / 21	1%	0.05	7 / 504
skin	40%	54.79	723 / 1809	1%	0.03	7 / 472
pancreas	22%	9.09	73 / 328	3%	0.07	6 / 178
lymph node	0%	0	0 / 0	10%	0.31	3 / 29
eye	0%	0	0 / 0	1%	0.03	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0051260	Biological process	protein homooligomerization
GO_0046050	Biological process	UMP catabolic process
GO_0046079	Biological process	dUMP catabolic process
GO_0001889	Biological process	liver development
GO_0051289	Biological process	protein homotetramerization
GO_0006248	Biological process	CMP catabolic process
GO_0001701	Biological process	in utero embryonic development
GO_0046135	Biological process	pyrimidine nucleoside catabolic process
GO_0006249	Biological process	dCMP catabolic process
GO_0033396	Biological process	beta-alanine biosynthetic process via 3-ureidopropionate
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0042803	Molecular function	protein homodimerization activity
GO_0003837	Molecular function	beta-ureidopropionase activity
GO_0008270	Molecular function	zinc ion binding

Gene name	UPB1
Protein name	UPB1 protein Beta-ureidopropionase (EC 3.5.1.6) (BUP-1) (Beta-alanine synthase) (N-carbamoyl-beta-alanine amidohydrolase) Beta-ureidopropionase 1
Synonyms	BUP1 DKFZp779O1248
Description	FUNCTION: Catalyzes a late step in pyrimidine degradation . Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide . Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable). .
Accessions	A4QPH4 Q6AHZ8 Q9UBR1 ENST00000415388.5 ENST00000382760.2 F8WC94 ENST00000326010.10

UPB1 report