UGT2B15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT2B15 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0008202Biological processsteroid metabolic process
GO_0052695Biological processcellular glucuronidation
GO_0008210Biological processestrogen metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0001972Molecular functionretinoic acid binding

IV. Literature review

[source]
Gene nameUGT2B15
Protein nameUDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (UGT2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)
UDP-glucuronosyltransferase UGT2B15
UDP-glucuronosyltransferase (EC 2.4.1.17)
SynonymsUGT2B8
DescriptionFUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) . Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) . Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity). .

AccessionsQ9UHH3
P54855
A0A0G2JMZ5
ENST00000611777.2
ENST00000338206.6