UGT2A2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UGT2A2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT2A2 at tissue level.

III. Associated gene sets

GO_0008206Biological processbile acid metabolic process
GO_0052695Biological processcellular glucuronidation
GO_0005575Cellular componentcellular_component
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015020Molecular functionglucuronosyltransferase activity

IV. Literature review

[source]
Gene nameUGT2A2
Protein nameUDP-glucuronosyltransferase 2A2 (UDPGT 2A2) (EC 2.4.1.17)
Synonyms
DescriptionFUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous estrogen hormone estradiol . Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption . Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth . .

AccessionsP0DTE5
ENST00000604021.1 [P0DTE5-2]
ENST00000604629.6 [P0DTE5-1]