UGT2A1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UGT2A1 at tissue level.

III. Associated gene sets

GO_0007608Biological processsensory perception of smell
GO_0008206Biological processbile acid metabolic process
GO_0052695Biological processcellular glucuronidation
GO_0007606Biological processsensory perception of chemical stimulus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015020Molecular functionglucuronosyltransferase activity

IV. Literature review

[source]
Gene nameUGT2A1
Protein nameUDP-glucuronosyltransferase 2A1 (UDPGT 2A1) (UGT2A1) (EC 2.4.1.17)
UDP-glucuronosyltransferase 2A1
UDP-glucuronosyltransferase (EC 2.4.1.17)
UDP glucuronosyltransferase family 2 member A1 complex locus
Synonyms
DescriptionFUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) . Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption . Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction . Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth . .

AccessionsA0A140T9Z0
D6RFW5
ENST00000512704.5
ENST00000514019
ENST00000286604.9 [P0DTE4-5]
ENST00000514019.1 [P0DTE4-4]
ENST00000505512.1
ENST00000503640.5 [P0DTE4-1]
P0DTE4
D6RHF3