UCP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UCP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UCP1 at tissue level.

III. Associated gene sets

GO_0050873Biological processbrown fat cell differentiation
GO_0034614Biological processcellular response to reactive oxygen species
GO_1990542Biological processmitochondrial transmembrane transport
GO_0009266Biological processresponse to temperature stimulus
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0002024Biological processdiet induced thermogenesis
GO_0032870Biological processcellular response to hormone stimulus
GO_1990845Biological processadaptive thermogenesis
GO_0070417Biological processcellular response to cold
GO_1903426Biological processregulation of reactive oxygen species biosynthetic process
GO_0031667Biological processresponse to nutrient levels
GO_0009409Biological processresponse to cold
GO_1903495Biological processcellular response to dehydroepiandrosterone
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_1902600Biological processproton transmembrane transport
GO_0071398Biological processcellular response to fatty acid
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0019003Molecular functionGDP binding
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0036041Molecular functionlong-chain fatty acid binding
GO_0005525Molecular functionGTP binding
GO_0032555Molecular functionpurine ribonucleotide binding
GO_0017077Molecular functionoxidative phosphorylation uncoupler activity
GO_1901612Molecular functioncardiolipin binding
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameUCP1
Protein nameMitochondrial brown fat uncoupling protein 1 (UCP 1)
Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin)
SynonymsUCP
SLC25A7
DescriptionFUNCTION: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane . However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). .

FUNCTION: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. .

AccessionsQ4KMT7
ENST00000262999.4
P25874