Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 21% ± 4% | |
| Mueller cell | 4 studies | 20% ± 2% | |
| astrocyte | 4 studies | 20% ± 7% | |
| GABAergic neuron | 3 studies | 23% ± 4% | |
| glutamatergic neuron | 3 studies | 33% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 549.07 | 1445 / 1445 | 100% | 3.94 | 183 / 183 |
| brain | 100% | 540.49 | 2640 / 2642 | 100% | 4.09 | 705 / 705 |
| lung | 100% | 601.20 | 576 / 578 | 100% | 3.57 | 1155 / 1155 |
| breast | 100% | 644.04 | 459 / 459 | 99% | 3.54 | 1109 / 1118 |
| pancreas | 100% | 468.22 | 328 / 328 | 99% | 3.10 | 176 / 178 |
| ovary | 100% | 682.82 | 180 / 180 | 99% | 3.12 | 425 / 430 |
| uterus | 100% | 694.31 | 170 / 170 | 98% | 3.03 | 452 / 459 |
| prostate | 100% | 744.51 | 245 / 245 | 98% | 2.68 | 494 / 502 |
| stomach | 100% | 518.27 | 359 / 359 | 98% | 3.27 | 279 / 286 |
| thymus | 100% | 728.57 | 653 / 653 | 98% | 2.90 | 590 / 605 |
| bladder | 100% | 642.05 | 21 / 21 | 97% | 2.93 | 491 / 504 |
| intestine | 100% | 653.45 | 966 / 966 | 97% | 3.16 | 513 / 527 |
| kidney | 100% | 650.12 | 89 / 89 | 93% | 2.56 | 842 / 901 |
| skin | 100% | 619.06 | 1809 / 1809 | 88% | 2.75 | 417 / 472 |
| adrenal gland | 100% | 869.60 | 258 / 258 | 87% | 1.93 | 200 / 230 |
| liver | 100% | 464.94 | 226 / 226 | 83% | 1.75 | 335 / 406 |
| adipose | 100% | 557.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 872.59 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 2.70 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.51 | 1 / 1 |
| blood vessel | 100% | 480.18 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 271.95 | 796 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 281.57 | 843 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 2.21 | 28 / 29 |
| peripheral blood | 84% | 505.29 | 776 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 54% | 1.23 | 43 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031591 | Biological process | wybutosine biosynthetic process |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0000049 | Molecular function | tRNA binding |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0102524 | Molecular function | tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity |
| GO_0016706 | Molecular function | 2-oxoglutarate-dependent dioxygenase activity |
| Gene name | TYW5 |
| Protein name | tRNA wybutosine-synthesizing protein 5 (hTYW5) (tRNA yW-synthesizing protein 5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) cDNA FLJ78342 (tRNA-yW synthesizing protein 5) |
| Synonyms | C2orf60 |
| Description | FUNCTION: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. . |
| Accessions | ENST00000483328.5 ENST00000354611.9 [A2RUC4-1] ENST00000441832.1 A2RUC4 A8KAJ9 |
