TUBB8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TUBB8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TUBB8 at tissue level.

III. Associated gene sets

GO_0001556Biological processoocyte maturation
GO_0000278Biological processmitotic cell cycle
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0007056Biological processspindle assembly involved in female meiosis
GO_0072686Cellular componentmitotic spindle
GO_0072687Cellular componentmeiotic spindle
GO_0070062Cellular componentextracellular exosome
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005874Cellular componentmicrotubule
GO_0045171Cellular componentintercellular bridge
GO_0005737Cellular componentcytoplasm
GO_0005525Molecular functionGTP binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0003674Molecular functionmolecular_function
GO_0046872Molecular functionmetal ion binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameTUBB8
Protein nameTubulin beta-8 chain (Tubulin beta 8 class VIII)
Tubulin beta chain
Tubulin beta 8 class VIII
SynonymshCG_2017862
DescriptionFUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation . .

FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. .

FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. .

AccessionsA0A075B735
A0A075B724
ENST00000564130.2
A0A075B725
Q3ZCM7
ENST00000568866.5
ENST00000568584.6
ENST00000562809.1
A0A075B736
ENST00000567466.1
ENST00000561967.1
Q5SQY0