TTLL9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018095Biological processprotein polyglutamylation
GO_0030317Biological processflagellated sperm motility
GO_0036211Biological processprotein modification process
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0031514Cellular componentmotile cilium
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0070740Molecular functiontubulin-glutamic acid ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL9
Protein nameTubulin--tyrosine ligase-like protein 9
Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9)
Tubulin tyrosine ligase like 9
SynonymsC20orf125
DescriptionFUNCTION: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern. .

AccessionsENST00000612972.1
A0A087WYL2
A0A0A0MR21
A0A087X135
ENST00000642230.1
ENST00000620043.4
A0A2R8Y6A5
ENST00000375938.8 [Q3SXZ7-1]
ENST00000644596.1
B4DZ96
ENST00000619753.1
A0A2R8YD21
ENST00000310998.8
A0A087WWB8
Q3SXZ7
ENST00000375922.8 [Q3SXZ7-2]
ENST00000535842.6 [Q3SXZ7-1]
ENST00000375921.6
ENST00000375934.8