TTLL4 | OmnibusX

Name	Number of supported studies	Average coverage
Mueller cell	4 studies	23% ± 7%	Explore
astrocyte	4 studies	32% ± 6%	Explore
retinal pigment epithelial cell	3 studies	26% ± 9%	Explore
oligodendrocyte	3 studies	16% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TTLL4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1236.89	1445 / 1445	100%	21.16	183 / 183
intestine	100%	1316.10	966 / 966	100%	16.09	527 / 527
skin	100%	1720.70	1809 / 1809	100%	36.37	472 / 472
stomach	100%	1124.24	359 / 359	100%	17.80	286 / 286
lung	100%	1834.47	578 / 578	100%	14.79	1151 / 1155
brain	100%	1355.10	2632 / 2642	100%	18.08	705 / 705
ovary	100%	1113.59	180 / 180	99%	14.76	426 / 430
pancreas	100%	1019.49	328 / 328	99%	10.91	176 / 178
breast	100%	1562.02	459 / 459	99%	16.10	1105 / 1118
uterus	100%	1411.86	170 / 170	98%	12.85	452 / 459
bladder	100%	1170.95	21 / 21	98%	11.14	496 / 504
prostate	100%	1927.95	245 / 245	98%	7.68	490 / 502
kidney	100%	1090.34	89 / 89	86%	6.73	774 / 901
thymus	100%	1087.10	652 / 653	83%	4.24	502 / 605
liver	100%	847.57	226 / 226	74%	10.20	302 / 406
adrenal gland	100%	1748.43	258 / 258	71%	5.12	163 / 230
eye	0%	0	0 / 0	100%	19.89	80 / 80
lymph node	0%	0	0 / 0	100%	11.73	29 / 29
spleen	100%	1536.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.53	45 / 45
ureter	0%	0	0 / 0	100%	5.00	1 / 1
adipose	100%	1003.80	1203 / 1204	0%	0	0 / 0
blood vessel	99%	873.87	1321 / 1335	0%	0	0 / 0
peripheral blood	98%	1563.43	910 / 929	0%	0	0 / 0
heart	97%	740.05	833 / 861	0%	0	0 / 0
muscle	94%	699.38	753 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0018095	Biological process	protein polyglutamylation
GO_0018200	Biological process	peptidyl-glutamic acid modification
GO_0120222	Biological process	regulation of blastocyst development
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0097731	Cellular component	9+0 non-motile cilium
GO_0005929	Cellular component	cilium
GO_0036064	Cellular component	ciliary basal body
GO_0005829	Cellular component	cytosol
GO_0005874	Cellular component	microtubule
GO_0070739	Molecular function	protein-glutamic acid ligase activity
GO_0070740	Molecular function	tubulin-glutamic acid ligase activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0015631	Molecular function	tubulin binding

Gene name	TTLL4
Protein name	Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) Tubulin tyrosine ligase like 4
Synonyms	KIAA0173
Description	FUNCTION: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. .
Accessions	ENST00000437755.1 C9J3I1 C9JB60 Q14679 H7BZY4 H7C2S3 ENST00000434241.1 ENST00000415717.5 H7C421 ENST00000392102.6 E9PH58 C9J982 ENST00000258398.8 E7EX20 ENST00000417196.5 ENST00000457313.5 H7C1F7 H7C470 ENST00000417855.1 ENST00000436668.5 ENST00000448224.1 ENST00000442769.5 ENST00000424644.1

TTLL4 report