TTLL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TTLL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TTLL2 at tissue level.

III. Associated gene sets

GO_0018095Biological processprotein polyglutamylation
GO_0036211Biological processprotein modification process
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0005929Cellular componentcilium
GO_0070740Molecular functiontubulin-glutamic acid ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL2
Protein nameTubulin tyrosine ligase like 2
Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2)
SynonymsC6orf104
DescriptionFUNCTION: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (By similarity). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (By similarity). Probably involved in the side-chain initiation step of the polyglutamylation reaction rather than the elongation step (By similarity). .

AccessionsENST00000239587.10
ENST00000515138.1
ENST00000512917.1
A0A3B3IRU1
Q9BWV7
D6R9R4
ENST00000649884.1