TTLL13 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TTLL13 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TTLL13 at tissue level.

III. Associated gene sets

GO_0018095Biological processprotein polyglutamylation
GO_0036211Biological processprotein modification process
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0005874Cellular componentmicrotubule
GO_0070740Molecular functiontubulin-glutamic acid ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL13
Protein nameTubulin tyrosine ligase like 13
Tubulin polyglutamylase TTLL13 (EC 6.3.2.-) (Tubulin tyrosine ligase like 13) (Tubulin tyrosine ligase-like family member 13 pseudogene) (Tubulin--tyrosine ligase-like protein 13)
SynonymsTTLL13P
DescriptionFUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Mediates ATP-dependent polyglutamate side-chain elongation of the polyglutamylation reaction but not the initiation step. Preferentially modifies the alpha-tubulin tail over a beta-tail. .

AccessionsA0A1W2PRM3
ENST00000621485.4
A6NNM8
A0A286YFC2
ENST00000438251.3 [A6NNM8-1]
A0A1W2PP44
ENST00000641754.2
ENST00000617037.4