TTLL11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018095Biological processprotein polyglutamylation
GO_0051013Biological processmicrotubule severing
GO_0036211Biological processprotein modification process
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0005829Cellular componentcytosol
GO_0005874Cellular componentmicrotubule
GO_0070740Molecular functiontubulin-glutamic acid ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL11
Protein nameTubulin polyglutamylase TTLL11 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 11)
Tubulin tyrosine ligase like 11
Tubulin tyrosine ligase-like family, member 11, isoform CRA_e (cDNA FLJ43188 fis, clone FCBBF3023895, weakly similar to Caenorhabditis elegans tubulin-tyrosine ligase)
SynonymsC9orf20
hCG_1818549
DescriptionFUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both spindle and cilia microtubules . Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (By similarity). .

AccessionsA0A087WUG8
ENST00000487468.5
ENST00000685478.1
ENST00000321582.11 [Q8NHH1-1]
A0AA75MRL2
Q6ZUZ3
A0A087WU58
ENST00000474723.5
ENST00000373776.5 [Q8NHH1-2]
ENST00000373778.5
Q8NHH1
A0A087WVF6