TTLL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TTLL1 at tissue level.

III. Associated gene sets

GO_0018095Biological processprotein polyglutamylation
GO_0007288Biological processsperm axoneme assembly
GO_0021702Biological processcerebellar Purkinje cell differentiation
GO_0120197Biological processmucociliary clearance
GO_0120222Biological processregulation of blastocyst development
GO_0002395Biological processimmune response in nasopharyngeal-associated lymphoid tissue
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0031514Cellular componentmotile cilium
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0005576Cellular componentextracellular region
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0070740Molecular functiontubulin-glutamic acid ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameTTLL1
Protein namePolyglutamylase complex subunit TTLL1 (EC 6.3.2.-) (Tubulin polyglutamylase TTLL1) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1)
SynonymsC22orf7
DescriptionFUNCTION: Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin . Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. .

AccessionsENST00000331018.8 [O95922-4]
O95922
ENST00000440761.1 [O95922-2]
ENST00000439248.5 [O95922-2]
ENST00000266254.12 [O95922-1]