TTI2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TTI2 at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_2000003Biological processpositive regulation of DNA damage checkpoint
GO_0050821Biological processprotein stabilization
GO_0110078Cellular componentTTT Hsp90 cochaperone complex
GO_0005634Cellular componentnucleus

IV. Literature review

[source]
Gene nameTTI2
Protein nameTELO2 interacting protein 2
TELO2-interacting protein 2
SynonymsC8orf41
DescriptionFUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. .

AccessionsQ6NXR4
ENST00000523305.1
ENST00000520636.5
ENST00000360742.9
ENST00000613904.1
E5RIH5
E5RHM7
ENST00000431156.7