TRUB1 | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	32% ± 5%	Explore
glutamatergic neuron	3 studies	42% ± 5%	Explore

Name	Number of supported studies	Average coverage
brain	4 studies	27% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	701.42	1442 / 1445	100%	28.50	183 / 183
ovary	100%	1128.53	180 / 180	100%	30.63	429 / 430
brain	100%	1011.17	2633 / 2642	100%	21.46	703 / 705
breast	100%	796.98	459 / 459	99%	32.60	1110 / 1118
prostate	100%	739.61	245 / 245	98%	24.67	492 / 502
intestine	100%	737.44	966 / 966	98%	24.11	516 / 527
thymus	100%	846.13	653 / 653	98%	22.69	592 / 605
adrenal gland	100%	2625.97	258 / 258	98%	26.17	225 / 230
stomach	99%	562.70	357 / 359	98%	25.36	281 / 286
kidney	100%	773.49	89 / 89	97%	21.97	871 / 901
bladder	100%	727.38	21 / 21	97%	20.23	487 / 504
uterus	100%	959.59	170 / 170	97%	20.29	443 / 459
pancreas	98%	451.36	322 / 328	97%	15.52	172 / 178
lung	91%	508.61	528 / 578	100%	26.19	1153 / 1155
skin	100%	935.70	1802 / 1809	91%	19.99	430 / 472
liver	100%	531.59	226 / 226	82%	10.36	333 / 406
adipose	100%	745.46	1204 / 1204	0%	0	0 / 0
spleen	100%	637.04	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.90	1 / 1
blood vessel	100%	655.11	1331 / 1335	0%	0	0 / 0
muscle	98%	491.03	787 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	20.23	44 / 45
heart	94%	643.09	810 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	14.03	26 / 29
eye	0%	0	0 / 0	71%	11.75	57 / 80
peripheral blood	36%	455.02	338 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1990481	Biological process	mRNA pseudouridine synthesis
GO_0006397	Biological process	mRNA processing
GO_2000633	Biological process	positive regulation of pre-miRNA processing
GO_0006400	Biological process	tRNA modification
GO_0005829	Cellular component	cytosol
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0009982	Molecular function	pseudouridine synthase activity
GO_0070883	Molecular function	pre-miRNA binding
GO_0160148	Molecular function	tRNA pseudouridine(55) synthase activity

Gene name	TRUB1
Protein name	Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25)
Synonyms	PUS4
Description	FUNCTION: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs . Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure . Constitutes the major pseudouridine synthase acting on mRNAs . Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs . Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity . Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation . .
Accessions	Q8WWH5 ENST00000298746.5

TRUB1 report