TRNT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042780Biological processtRNA 3'-end processing
GO_0001680Biological processtRNA 3'-terminal CCA addition
GO_0106354Biological processtRNA surveillance
GO_0072344Biological processrescue of stalled ribosome
GO_1990180Biological processmitochondrial tRNA 3'-end processing
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004810Molecular functionCCA tRNA nucleotidyltransferase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0160016Molecular functionCCACCA tRNA nucleotidyltransferase activity
GO_0000049Molecular functiontRNA binding
GO_0034062Molecular function5'-3' RNA polymerase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameTRNT1
Protein nametRNA nucleotidyl transferase 1
CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)
SynonymsCGI-47
DescriptionFUNCTION: Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates . tRNA 3'-terminal CCA addition is required both for tRNA processing and repair . Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ANKZF1 and repair by ELAC1 . Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts . While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded . The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA . This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle . .; FUNCTION: [Isoform 2]: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro). .

AccessionsA0A494C1D4
ENST00000698410.1
A0A494BZV5
A0A8V8TN57
ENST00000698414.1
ENST00000280591.10 [Q96Q11-2]
ENST00000339437.11 [Q96Q11-3]
ENST00000651093.1
C9JRS7
A0A494C181
A0A494C1P4
ENST00000651352.1
ENST00000251607.11 [Q96Q11-1]
ENST00000397779.3
ENST00000650839.1
A0A494C1L4
ENST00000465998.2
ENST00000650755.1
ENST00000698411.1
A0A494C0N8
ENST00000652340.1
A0A494C0A0
ENST00000434583.5 [Q96Q11-1]
Q96Q11
ENST00000651316.1
ENST00000698413.1
ENST00000420393.5 [Q96Q11-3]
A0A494C0Y2
F8W8C3
ENST00000698406.1 [Q96Q11-1]
ENST00000650814.1
A0A8V8TM71
ENST00000402675.5 [Q96Q11-3]
ENST00000698408.1 [Q96Q11-1]
ENST00000413000.1
ENST00000698412.1 [Q96Q11-1]
ENST00000651591.1