Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 6 studies | 20% ± 4% | |
| endothelial cell | 4 studies | 22% ± 4% | |
| astrocyte | 3 studies | 19% ± 3% | |
| transit amplifying cell | 3 studies | 22% ± 4% | |
| oligodendrocyte | 3 studies | 15% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1402.96 | 1445 / 1445 | 100% | 10.79 | 183 / 183 |
| pancreas | 100% | 1175.46 | 328 / 328 | 100% | 9.08 | 178 / 178 |
| brain | 100% | 1446.44 | 2641 / 2642 | 100% | 12.24 | 705 / 705 |
| thymus | 100% | 1811.34 | 653 / 653 | 100% | 8.98 | 604 / 605 |
| lung | 100% | 1308.63 | 577 / 578 | 100% | 10.30 | 1155 / 1155 |
| intestine | 100% | 1460.36 | 966 / 966 | 100% | 10.42 | 526 / 527 |
| bladder | 100% | 1480.71 | 21 / 21 | 100% | 12.16 | 503 / 504 |
| prostate | 100% | 1954.28 | 245 / 245 | 100% | 9.93 | 501 / 502 |
| skin | 100% | 1611.11 | 1809 / 1809 | 100% | 14.30 | 471 / 472 |
| breast | 100% | 1372.42 | 459 / 459 | 100% | 8.51 | 1114 / 1118 |
| uterus | 100% | 1606.92 | 170 / 170 | 100% | 13.79 | 457 / 459 |
| liver | 100% | 1176.93 | 226 / 226 | 99% | 7.80 | 403 / 406 |
| kidney | 100% | 1869.88 | 89 / 89 | 99% | 7.63 | 894 / 901 |
| stomach | 100% | 1226.77 | 359 / 359 | 99% | 9.20 | 283 / 286 |
| ovary | 100% | 1622.44 | 180 / 180 | 98% | 6.76 | 423 / 430 |
| adrenal gland | 100% | 1648.09 | 258 / 258 | 98% | 8.11 | 226 / 230 |
| adipose | 100% | 1200.03 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 15.14 | 29 / 29 |
| spleen | 100% | 1979.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.16 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.70 | 1 / 1 |
| blood vessel | 100% | 1118.97 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 1506.65 | 858 / 861 | 0% | 0 | 0 / 0 |
| muscle | 100% | 782.81 | 800 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 7.44 | 79 / 80 |
| peripheral blood | 91% | 897.32 | 848 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002143 | Biological process | tRNA wobble position uridine thiolation |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0000049 | Molecular function | tRNA binding |
| GO_0061708 | Molecular function | tRNA-5-taurinomethyluridine 2-sulfurtransferase |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | TRMU |
| Protein name | Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) tRNA mitochondrial 2-thiouridylase Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog) Mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase transcript variant 1 (Mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase transcript variant 2) (tRNA mitochondrial 2-thiouridylase) cDNA FLJ52814, highly similar to tRNA(5-methylaminomethyl-2-thiouridylate)-methyltransferase (tRNA mitochondrial 2-thiouridylase) |
| Synonyms | TRMT1 MTU1 |
| Description | FUNCTION: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. . FUNCTION: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. . FUNCTION: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. . FUNCTION: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. . |
| Accessions | A0A2R8Y6L6 Q2PPL5 ENST00000441818.5 A0A2R8Y4R7 ENST00000453630.5 ENST00000456595.5 B4DZN5 A0A2R8YFQ3 ENST00000647301.1 ENST00000642562.1 ENST00000381019.3 [O75648-2] ENST00000643137.1 A0A2R8YDK3 ENST00000457572.5 [O75648-5] ENST00000644006.1 ENST00000381021.7 ENST00000645190.1 [O75648-1] O75648 ENST00000642923.1 |
