I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 21% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 21% ± 3% |
Insufficient scRNA-seq data for expression of TRMT5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 997.85 | 459 / 459 | 100% | 15.20 | 1118 / 1118 |
| esophagus | 100% | 890.84 | 1445 / 1445 | 100% | 12.14 | 183 / 183 |
| ovary | 100% | 1018.34 | 180 / 180 | 100% | 10.46 | 430 / 430 |
| pancreas | 100% | 654.87 | 328 / 328 | 100% | 9.58 | 178 / 178 |
| prostate | 100% | 881.36 | 245 / 245 | 100% | 13.61 | 502 / 502 |
| stomach | 100% | 653.21 | 359 / 359 | 100% | 10.20 | 286 / 286 |
| uterus | 100% | 870.60 | 170 / 170 | 100% | 12.36 | 459 / 459 |
| thymus | 100% | 839.54 | 653 / 653 | 100% | 9.92 | 604 / 605 |
| brain | 100% | 675.56 | 2637 / 2642 | 100% | 19.91 | 705 / 705 |
| intestine | 100% | 836.45 | 966 / 966 | 100% | 11.03 | 526 / 527 |
| bladder | 100% | 924.81 | 21 / 21 | 100% | 11.11 | 502 / 504 |
| liver | 100% | 490.25 | 226 / 226 | 99% | 6.25 | 403 / 406 |
| kidney | 100% | 671.71 | 89 / 89 | 99% | 8.59 | 894 / 901 |
| skin | 100% | 1225.64 | 1808 / 1809 | 99% | 12.95 | 466 / 472 |
| lung | 98% | 592.58 | 569 / 578 | 100% | 12.23 | 1155 / 1155 |
| adrenal gland | 100% | 890.82 | 258 / 258 | 98% | 8.93 | 226 / 230 |
| adipose | 100% | 953.35 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 696.51 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.19 | 29 / 29 |
| spleen | 100% | 707.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 11.81 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.79 | 1 / 1 |
| muscle | 100% | 690.16 | 802 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 9.95 | 77 / 80 |
| heart | 96% | 427.18 | 826 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 40% | 380.78 | 368 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0070901 | Biological process | mitochondrial tRNA methylation |
| GO_0002939 | Biological process | tRNA N1-guanine methylation |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008175 | Molecular function | tRNA methyltransferase activity |
| GO_0052906 | Molecular function | tRNA (guanine(37)-N1)-methyltransferase activity |
| Gene name | TRMT5 |
| Protein name | tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) tRNA methyltransferase 5 |
| Synonyms | TRM5 KIAA1393 |
| Description | FUNCTION: Involved in mitochondrial tRNA methylation . Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. . |
| Accessions | Q32P41 G3V494 ENST00000553903.1 ENST00000555420.1 ENST00000261249.7 G3V5X1 |
