TRIM45 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM45 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM45 at tissue level.

III. Associated gene sets

GO_0070936Biological processprotein K48-linked ubiquitination
GO_0050728Biological processnegative regulation of inflammatory response
GO_0060348Biological processbone development
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0045171Cellular componentintercellular bridge
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM45
Protein nameE3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)
Tripartite motif containing 45
SynonymsRNF99
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response . Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response . May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. .

AccessionsENST00000256649.9 [Q9H8W5-1]
Q5T2K3
ENST00000485032.1
ENST00000369461.3
H0YCA7
Q9H8W5
ENST00000369464.7 [Q9H8W5-2]
S4R407
ENST00000497970.5