TPM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007015Biological processactin filament organization
GO_0043462Biological processregulation of ATP-dependent activity
GO_0006936Biological processmuscle contraction
GO_0005862Cellular componentmuscle thin filament tropomyosin
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005884Cellular componentactin filament
GO_0046982Molecular functionprotein heterodimerization activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0051015Molecular functionactin filament binding
GO_0042802Molecular functionidentical protein binding
GO_0003779Molecular functionactin binding
GO_0008307Molecular functionstructural constituent of muscle

IV. Literature review

[source]
Gene nameTPM2
Protein nameTropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)
SynonymsTPM2b
TMSB
DescriptionFUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. .

AccessionsA0A2R8Y6A3
ENST00000378292.9 [P07951-2]
ENST00000644325.1
ENST00000645482.3 [P07951-1]
U3KQK2
A7XZE4
Q5TCU3
P07951
ENST00000329305.6
ENST00000607559.1
ENST00000647435.1